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KMID : 0545120100200101436
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 10 p.1436 ~ p.1439
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Chelation of Calcium Ions by Poly(γ-Glutamic Acid) from Bacillus subtilis(Chungkookjang)
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Takashi Tsujimoto
Junya Kimura
Yasushi Takeuchi
Hiroshi Uyama
Park Chung
Sung Moon-Hee
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Abstract
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Many studies have clarified that poly(γ-glutamic acid) (PGA) increases the solubility of Ca2+, suggesting that PGA enhances calcium absorption in small intestine. However, there has been no report on the specific interaction between PGA and Ca2+ in water. We studied the aqueous solution properties of PGA calcium salt (PGA Ca). The chelating ability and binding strength of PGA for Ca2+ were evaluated. PGA Ca was soluble in water in contrast with the insolubility of poly(acrylic acid) (PAA) calcium salt and the chelating ability of PGA for Ca2+ was almost the same than that of PAA. The globular conformation of PGA Ca in water was estimated by SEC and viscosity measurements. The chelation of PGA for Ca2+ was examined by 1H NMR. The present study showing the characteristics of PGA Ca will provide useful information of the calcium absorption by PGA in vivo.
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KEYWORD
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poly(γ glutamic acid), Bacillus subtilis chungkookjang, chelation, calcium ion
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